The daughter of Quentin Beck, the original Mysterio, Francine Beck sought justice for her father after his apparent death, when he became trapped within his magically-empowered spherical helmet during a confrontation against Spider-Man. To this end, Francine disguised herself as a little girl and deceived Spider-Man into letting her enter the Sanctum Sanctorum, from where she retrieved her father's helmet.
After putting the helmet on, Francine discovered Quentin had remained imprisoned inside it all this time due to a spell of its creator, the dreaded Dormammu. With the help of Spider-Man and Moon Knight, they both were able to escape the helmet's illusion and be a family again.
And she is reprised by Mary Kate Wiles in the English dub and will be voiced by Keito Kitagawa in the Japanese dub.