Hades may refer to:
- Emperor of Darkness/Hades, the ruler of the underworld and arch-nemesis of Zeus.
- Hades, the evolved version of Alpha Hydranoid and used by Shadow Prove.
- Hades, one of the Gods of Olympus, but rules the Underworld as he was the second son of Cronus.
- Hades, the ruler of the Underworld and the second boss of the third God of War game.
- Hades, the main antagonist of Hercules, who turned over a new leaf to join the Resistance after Kazuya played him for a fool after releasing the Titans a second time.
- Hades, the final boss and the supreme leader of the Underworld Army after Medusa failed him.
- Hades, a Greek deity and brother of Poseidon and Zeus and the final antagonist of Saint Seiya.
- Hades, one of the playable Greek Gods in Smite.
- Hades, the true final boss of Warriors Orochi.
- Hades: Izanami, one of the main antagonists of the BlazBlue series.
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