Cackletta is an evil witch from the Beanbean Kingdom and is the main antagonist of Mario & Luigi: Superstar Saga for the Game Boy Advance, and its 3DS remake. She also appeared as a Sticker in Super Smash Bros. Brawl.
Throughout the whole game, Cackletta is often with Fawful, her assistant. Early in the game, Cackletta disguises herself as The Goodwill Ambassador to steal Princess Peach's voice and uses it to steal the Beanstar. She also replaced the latter's voice with "explosive vocabulary", which is composed of various symbols that drop from her speech bubble to the ground and cause minor explosions. Beanbean lore states that only one with a beautiful voice can activate the Beanstar's mysterious powers to grant any wishes; Cackletta hopes to use this power to conquer the Beanbean Kingdom and soon after, the Mushroom Kingdom. The Mario Bros. go to the Beanbean Kingdom to stop her, and they meet her for the first time on the Koopa Cruiser when she and Fawful come to attack. She later comes to Beanbean Castle Town, attacks it, and also feeds Queen Bean a Belly Blech worm, which turns her into a monster. She then encounters the Mario Bros. again in Beanbean Castle and tricks them into fixing the castle's plumbing, which turns off the Beanstar's security system and allows Cackletta to steal the Beanstar. Mario rushes up to the throne room to stop her, but it is too late; Cackletta and Fawful get away and leave Queen Bean, under the influence of the worm, to take care of the Mario Bros. Later, Cackletta goes to Woohoo Hooniversity to carry out her plans with the Beanstar, also transforming several of the researchers into monsters. After Queen Bean is restored to normal and the Castle Town is repaired, the Mario Bros. travel to Woohoo Hooniversity.
Cackletta activating three Peach-bots, which are robots programmed to play a perfect copy of the stolen voice.
Cackletta's plans backfire, however, when she attempts to use Peach's voice by putting the voice in robots codenamed "Peach-bots". It is later revealed that Toadsworth and others of the Mushroom Kingdom avoided the Plot and switched Peach with Birdo, whom they dressed up like Peach. As a result, the Beanstar becomes furious by Birdo's voice and does not help Cackletta at all. Instead, the Mario Bros. come and give her a surprise attack at the wrong time, and the pair finally battle Cackletta.
They fight until Cackletta is so badly injured, she cannot move. Fawful comes and absorbs Cackletta's body in his "headgear". Cackletta then commands Fawful to do one more attack for her, however, he is stopped by Prince Peasley hitting them with his sword and knocking them out of Woohoo Hooniversity.
Bowser is lying unconscious in the Mushroom Kingdom side of Stardust Fields when Fawful lands there, too, and puts Cackletta's ghost into Bowser's body and thus, the birth of "Bowletta". Now that Bowletta can control Beanbean minions and Koopa minions, she is more powerful than ever and plots to steal the Beanstar again and get the real Peach's voice. She succeeds in kidnapping Princess Peach in Little Fungitown while Mario is sick with Bean Fever and Luigi is searching for the antidote in Guffawha Ruins. She then offers a deal with the Mario Bros. through a video recording: find the Beanstar pieces and fix them, then give her the Beanstar and she will return Peach. The brothers' friends at the castle realize that Bowletta is probably tricking them and not planning to return Peach. Prince Peasley has a plan to give her a fake Beanstar and meet them at the top of Joke's End. After many long battles, the Bros. finally make it up to the top of Joke's End. Luigi gives Fawful the fake Beanstar, but Fawful sees right through the disguise and knocks down the Bros'. suitcase.
Mario follows after Luigi and they have an idea. Mario and Luigi come to Bowletta, but Bowletta refuses to honor the deal and release Peach. A few minutes later another Princess Peach comes out along with Mario, holding her mouth. Mario cracks up and Bowletta understands that the Peach she's holding is a fake. She drops the Peach she's holding and grabs the other. They then go to the Koopa Cruiser and ask her why she's holding her mouth, but she doesn't respond. Then Bowletta scares her to reveal a big mustache, and the "real" Peach turns out to be Luigi, forcing him to make a getaway.
In the mean time, Bowletta plans a plot to destroy the Beanbean Kingdom and then, after the Bros. are destroyed, the Mushroom Kingdom. She goes in Bowser's Castle and successfully destroys Beanbean Castle Town. The Bros. go to Hoohoo Village and tell Blablanadon that Bowser's Castle is overhead and now he should take them up. Fawful then informs Bowletta that the Mario Bros. are coming so Bowletta orders the seven Koopalings and Fawful to guard her castle. The Bros. fight them all and eventually fight Bowletta until finally she gets an idea. She pretends to be defeated and then, when they let their guards down, she summons a Time Bob-omb to explode at them. It works and she subsequently swallows them. Inside Bowletta's stomach, Mario and Luigi, barely conscious, find Cackletta's spirit inside of the body and fight her.
After Cackletta is defeated, her spirit leaves Bowser's body, disappearing into the afterlife and Bowser returns to his original form.
And she is voiced by Linda Young in the English dub and her Japanese voice is unknown.